800 mm ID dynamic axial compression column — ≤ 7 MPa working pressure, Ra ≤ 0.2 µm internal finish and H-TREE radial flow distribution in SUS 316L.
An industrial-scale dynamic axial compression (DAC) column for the preparative purification of synthetic peptides, oligonucleotides and small-molecule APIs. A pneumatic hydraulic pump drives the piston to pack, maintain and discharge the bed, giving a stable, reproducible bed height from gram-scale method development up to multi-kilogram production campaigns.
Engineered for reproducible preparative separations at process scale.
| Cat. No. | DAC-RNE90370 |
| Column inner diameter | 800 mm |
| Standard column length | 650 mm |
| Effective packed bed height | ≤ 350 mm |
| Internal wall roughness | ≤ 0.2 µm (Ra), mirror polished |
| Max. working pressure | ≤ 7 MPa |
| Hydraulic cylinder design | ≤ 25 MPa |
| End cap connection | Bolted connection (quick chain clamp) |
| Flow distribution | H-TREE radial distributor, mirror polished |
| Seal design | Three-layer (bowl ring + active ring + oriented ring) |
| Wetted materials | SUS 316L · PTFE · PEEK · FEP + SI cladding O-rings |
| Frit | SS316L, 2 µm porosity |
| Hydraulic cylinder material | 45# quality carbon steel, 25–30 HRC, hard-chrome piston rod |
| Rack material | SUS 304 |
| Packing method | Down packing |
| Column dimensions | 2400 × 1900 × 4300 mm (final dimensions confirmed at DQ) |
| Total weight | ≈ 15,000 kg (column + oil tank + turnover rack + storage rack) |
| Instrumentation | Pressure gauge MAXIMATOR 0–250 bar · air-driven pump HYDR-STAR · check valve JPE · relief valve VSLOK · pneumatic valves VSTORK |
| Slurry tank (ST350) | 350 L · pneumatic motor drive · mechanical seal · pneumatic diaphragm pump · 5–7 bar compressed air |
| Validation package | DQ · FAT · IQ · OQ · material reports · installation/operation manuals · spare-parts list |
| Service | 1-year warranty · 24-hour response · on-site commissioning & operator training |
The column bed is formed and maintained under controlled hydraulic pressure, so bed height and resolution stay reproducible from run to run and scale-up remains linear.
The 350 L ST350 tank mixes packing solvent and stationary phase with a pneumatic stirrer and feeds the column via diaphragm pump.
Down packing with the hydraulic cylinder driving the piston to compress the bed to the target height (≤ 350 mm).
The cylinder maintains bed compression throughout the run.
Mobile phase is pumped through the radial distributor until the bed is stable and baseline is reached.
Sample is loaded and fractions are collected at production flow rates.
The piston rises to discharge the bed; wetted parts are dismantled for cleaning without moving the column.
Engineered for reproducible preparative separations at process scale.
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All DIAGNOSEX process equipment is designed and manufactured in accordance with GMP / cGMP principles. Documentation packages supporting regulatory submissions — including material certificates, calibration records, and design qualifications — are available upon request.
Yes. Vial and stopper formats, throughput, automation level, cleanroom classification, and integration with upstream or downstream equipment can all be tailored to your process. Share your requirements and our engineers will propose a configuration.
Standard configurations generally ship within 8–12 weeks after order confirmation. Customized or fully integrated lines typically require 12–16 weeks, depending on the scope of engineering involved.
Yes. Our engineers provide on-site installation, commissioning, and structured operator and maintenance training. Remote commissioning support and English-language video training are also available.
